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A drug, chemical, or other ... Substance Definition of Substance by Merriam Webster Define substance: a material of a particular kind substance in a sentence Substance Define Substance at Dictionary.com Substance definition, that of which a thing consists; physical matter or material: form and substance. See more. Prevention of Substance Abuse and Mental Illness SAMHSA ... SAMHSA promotes and implements prevention and early intervention strategies to reduce the impact of mental and substance use disorders in Americas communities. Substance dictionary definition substance defined An example of substance is when an argument makes sense and has facts to back it up. Substance is a person who is smart and interested in the world. Substance Use and Adolescent Development HHS.gov Learn more about adolescent substance abuse issues and ways to prevent it. DrugFacts: Treatment Approaches for Drug Addiction ... ... you can call the Substance Abuse and Mental Health Services Administration's ... 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